TRANSDUODENAL AMPULLECTOMY IS AN EFFECTIVE SURGICAL EXPLORATION PROCEDURE FOR UNEXPLAINED DILATION OF THE CHOLANGIOPANCREATIC DUCT

Transduodenal ampullectomy is an effective surgical exploration procedure for unexplained dilation of the cholangiopancreatic duct

Abstract Background The clinical diagnosis and treatment of dilation of the cholangiopancreatic duct in patients with ambiguous ampullary disease, termed unexplained dilation of the cholangiopancreatic duct (UDCD), is commonly difficult.This study aimed to evaluate the applicability of transduodenal ampullectomy (TDA) for the diagnosis and treatmen

read more

Cell death regulation by MAMs: from molecular mechanisms to therapeutic implications in cardiovascular diseases

Abstract The endoplasmic reticulum (ER) and mitochondria are interconnected intracellular organelles with vital roles in the regulation of cell signaling and function.While the ER participates in a number of biological processes including lipid biosynthesis, Ca2+ storage and protein folding and processing, mitochondria are highly dynamic organelles

read more

Physiologic effects of alveolar recruitment and inspiratory pauses during moderately-high-frequency ventilation delivered by a conventional ventilator in a severe lung injury model.

To investigate whether performing alveolar recruitment or adding inspiratory pauses could promote physiologic benefits (VT) during moderately-high-frequency positive pressure ventilation (MHFPPV) delivered by a conventional ventilator in a porcine model of severe acute respiratory distress syndrome (ARDS).Prospective experimental laboratory study w

read more

Nicotinamide adenine dinucleotide phosphate oxidase 2 deletion attenuates polyhexamethylene guanidine-induced lung injury in mice

Inhalation of polyhexamethylene guanidine phosphate (PHMG) can cause pulmonary fibrosis.Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (Nox) are enzymes that produce reactive oxygen species, which may be involved in tissue damage in various lung diseases.To investigate whether the Nox2 isoform of Nox is involved in the progression of

read more